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                                                     Your resource for cryopreservation of reproductive cells and tissues

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Poor pregnancy rates from seemingly good embryos that survive cryopreservation can be the result of several things.  Two areas to focus on are embryo quality and uterine preparation and support. 

As far as embryo quality goes, the embryos may look very good and survive vitrification, but the fact that they do not implant or maintain a pregnancy suggests that they may be fine when they are fresh, but the insult of freezing, stresses them enough to produce poor pregnancy results, even though they may look good.  Critically look at the embryo quality and your culture system to make sure the problem does not lie there. 

 The second area to examine is how you prepare the uterus of frozen embryo transfer patients.  These patients are not on a full stimulation cycle and thus, in most cases,  should have an even better uterine environment to receive an embryo.  The implantation rate should be similar to when using fresh embryos.  If the FHB rate is poor and the incidence of biochemicals are high then progesterone supplementation may be a factor.  Progesterone given i.m. versus orally should be examined.  There are other more experienced people that should be consulted if this is a problem your clinic faces.  We can suggest a few for you. 

Keep in mind, that there are over 35 clinics successfully using the ICE Vitrification system/media so we are confidant that there is nothing wrong with the media/system, and, most likely, the problem lies elsewhere.   Dealing with past issues has led us to realize that the main problems lie with either not following the protocol or poor embryo/egg quality to begin with.  Remember that the ICE Vitrification system is very different than other vitrification systems, and different rules may apply.  

Please contact us with any and all questions you may have.  If you don't understand something we can help.  A complete understanding of the system/protocol is the first step to obtaining great results.

 

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